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Our studies indicate that RyR2 from seven out of the eight animals contain both FKBP12 and 12
Until recently, canine cardiac sarcoplasmic reticulum was considered to be the prototype for studying heart RyR2 and its interactions with FKBP FK506 binding protein FKBP is a cytosolic receptor for the immunosuppressive drug FK-506

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In this study, cardiac microsomes were isolated from diverse vertebrates: human, rabbit, rat, mice, dog, chicken, frog, and fish and were analyzed for their ability to bind or exchange with FKBP isoforms 12 and 12.

فقاريات
The common isoform, FKBP12, was found to be associated with the calcium release channel ryanodine receptor 1 of different species of vertebrate skeletal muscle, whereas 12
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It can now be concluded that the association of FKBP isoforms with RyR2 is widely conserved in the hearts of different species of vertebrates
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6, a novel FKBP isoform was found to be associated with canine cardiac ryanodine receptor ryanodine receptor 2

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خصائص الفقاريات ، التصنيف ، الجهاز العصبي ، الجهاز الهضمي ، التكاثر / علم الاحياء
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